HORDB

ID: hor004434
Uniprot ID: P41540
Protein name: Substance P
Gene name: Tac1
Organism: Oryctolagus cuniculus (Rabbit)
Family: Tachykinin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Oryctolagus (genus), Leporidae (family), Lagomorpha (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission
GO CC: GO:0005576 extracellular region; GO:0045202 synapse

Sequence: RPKPQQFFGLM
Length: 11(58-68)
Propeptide: MKILVALAVLALVSTQLFAEDIRANDDLNYWSDWSDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDAGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK
Signal peptide: MKILVALAVLALVSTQLFA
Modification: T11 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Function: Excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles
Mechanism: NA
Cross BBB: YES
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: 2.1 (t1/2 of hydrolysis) minutes; /126 seconds ( PubMed ID: 7529108 )

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004434_AF2.pdb

hor004434_ESM.pdb

Mass:	152717	Formula:	C63H97N17O14S
Absent amino acids:	ACDEHINSTVWY	Common amino acids:	FPQ
pI:	11.65	Basic residues:	2
Polar residues:	1	Hydrophobic residues:	3
Hydrophobicity:	-70	Boman Index:	-1738
Half-Life:	1 hour	Half-Life Yeast:	2 min
Half-Life E.Coli:	2 min	Aliphatic Index	35.45
Instability Index:	4790.91	Extinction Coefficient cystines:	0
Absorbance 280nm:	0